Document Type
Article
Version Deposited
Published Version
Publication Date
2-1-2024
Publication Title
Investigative Ophthalmology & Visual Science
DOI
10.1167/iovs.65.2.14
Abstract
Albinism is a spectrum disorder causing foveal hypoplasia, nystagmus, and hypopigmentation of the iris and fundus along with other visual deficits, which can all impact vision. Albinism is also associated with amblyogenic factors which could affect monocular visual acuity. The foveal appearance in albinism can range from mild foveal hypoplasia to that which is indistinguishable from the peripheral retina. The appearance can be quickly and easily graded using the Leicester Grading System in the clinic. However, interquartile ranges of 0.3 logMAR for the grades associated with albinism limit the accuracy of the grading system in predicting vision. Here, we discuss the potential role of nystagmus presenting evidence that it may not be a major source of variability in the prediction of visual acuity. We also show that interocular differences in visual acuity are low in albinism despite high levels of amblyogenic factors indicating that active suppression of vision in one eye in albinism is uncommon.
Recommended Citation
Frank A. Proudlock, Rebecca J. McLean, Viral Sheth, Sarim Ather, Irene Gottlob; Phenotypic Features Determining Visual Acuity in Albinism and the Role of Amblyogenic Factors. Invest. Ophthalmol. Vis. Sci. 2024;65(2):14. https://doi.org/10.1167/iovs.65.2.14.
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Comments
Copyright 2024 The Authors This work is licensed under a Creative Commons Attribution 4.0 International License.