HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers

Authors

Preeti Putcha
Jiyang Yu
Ruth Rodriguez-Barrueco
Laura Saucedo-Cuevas
Patricia Villagrasa
Eva Murga-Penas
Steven N. Quayle
Min Yang
Veronica Castro
David Llobet-Navas
Daniel Birbaum
Pascal Finetti
Wendy A. Woodward
Francois Bertucci
Mary AlpaughFollow
Andrea Califano
Jose Silva

Document Type

Article

Version Deposited

Published Version

Publication Date

12-8-2015

Publication Title

BioMed Central Breast Cancer Research

DOI

http://dx.doi.org/10.1186/s13058-015-0658-0

Abstract

Inflammatory breast cancer (IBC) is the most lethal form of breast cancers with a 5-year survival rate of only 40 %. Despite its lethality, IBC remains poorly understood which has greatly limited its therapeutic management. We thus decided to utilize an integrative functional genomic strategy to identify the Achilles’ heel of IBC cells.

Comments

This article is designated Open Access by BioMed Central.

Recommended Citation

Putcha, P., Yu, J., Rodriguez-Barrueco, R., Saucedo-Cuevas, L., Villagrasa, P., Murga-Penas, E., . . . Silva, J. (2015). HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers. Breast Cancer Research : BCR, 17(1), 149-015-0658-0.