Green Chemistry Letters and Reviews
Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.
Neuhaus, William C.; Bakanas, Ian J.; Lizza, Joseph R.; Boon, Charles T. Jr.; and Moura-Letts, Gustavo, "Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction" (2016). Faculty Scholarship for the College of Science & Mathematics. 33.
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