Modification of the Ribosome as Part of the Adaptive Response to Oxidative Stress in Yeast

Authors

Jessica A Zinskie, Rowan University
Daniel Shedlovskiy, Rowan University
Ethan Gardner, Rowan University
Dimitri G Pestov, Rowan University
Natalia Shcherbik, Rowan University

Document Type

Poster

Version Deposited

Published Version

Publication Date

12-15-2017

Publication Title

Molecular Biology of the Cell

Conference Name

2017 ASCB Annual Meeting

DOI

10.1091/mbc.E17-10-0618

Abstract

Living organisms are constantly exposed to a variety of environmental and internal stressors tha tare detrimental to their cellular physiology and viability. One such condition, oxidativestress, is caused by abnormal amounts of Reactive Oxygen Species (ROS) that can lead to damage to proteins, nucleic acids, and lipids. Although the mechanisms to neutralize ROS have been widely studied, the understanding of ROS‐mediated signaling for these mechanisms is rather incomplete and sparse. We have uncovered a previously undescribed phenomenon of yeast ribosomes to respond to elevated levels of ROS through a specific endonucleolytic cleavage of the 25S rRNA in the c‐loop of the expansion segment 7 (ES7c) regions.

Comments

The complete published abstracts are available as "Supplemental Materials" at https://www.molbiolcell.org/doi/10.1091/mbc.e17-10-0618

Recommended Citation

Zinskie JA, Shedlovskiy D, Gardner E, Pestov D, Shcherbik N. Modification of the ribosome as part of the adaptive response to oxidative stress in yeast [Conference Abstract P2552]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.

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