Document Type
Article
Version Deposited
Published Version
Publication Date
9-13-2023
Publication Title
PLoS One
DOI
10.1371/journal.pone.0289841
Abstract
BACKGROUND: The etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers. This study focused on two of these compounds, the Bisphenol-A (BPA) and Diethylhexyl Phthalate (DEHP). The major pathway for BPA and DEHP excretion is via glucuronidation. Glucuronidation makes insoluble substances more water-soluble allowing for their subsequent elimination in urine.
HYPOTHESIS: Detoxification of these two plasticizers is compromised in children with ASD and ADHD. Consequently, their tissues are more exposed to these two plasticizers.
METHODS: We measured the efficiency of glucuronidation in three groups of children, ASD (n = 66), ADHD (n = 46) and healthy controls (CTR, n = 37). The children were recruited from the clinics of Rutgers-NJ Medical School. A urine specimen was collected from each child. Multiple mass spectrometric analyses including the complete metabolome were determined and used to derive values for the efficiency of glucuronidation for 12 varied glucuronidation pathways including those for BPA and MEHP.
RESULTS: (1) Both fold differences and metabolome analyses showed that the three groups of children were metabolically different from each other. (2) Of the 12 pathways examined, only the BPA and DEHP pathways discriminated between the three groups. (3) Glucuronidation efficiencies for BPA were reduced by 11% for ASD (p = 0.020) and 17% for ADHD (p
CONCLUSION: ASD and ADHD are clinically and metabolically different but share a reduction in the efficiency of detoxification for both BPA and DEHP with the reductions for BPA being statistically significant.
Recommended Citation
Stein, T Peter; Schluter, Margaret D; Steer, Robert A; and Ming, Xue, "Bisphenol-A and Phthalate Metabolism in Children with Neurodevelopmental Disorders" (2023). Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship. 203.
https://rdw.rowan.edu/som_facpub/203
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Published Citation
Stein TP, Schluter MD, Steer RA, Ming X. Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders. PLoS One. 2023;18(9):e0289841. Published 2023 Sep 13. doi:10.1371/journal.pone.0289841
Included in
Developmental Neuroscience Commons, Disorders of Environmental Origin Commons, Endocrine System Diseases Commons, Environmental Public Health Commons, Neurology Commons, Other Chemicals and Drugs Commons, Pediatrics Commons
