Document Type
Article
Version Deposited
Published Version
Publication Date
8-29-2024
Publication Title
PCN Reports
DOI
10.1002/pcn5.70004
Abstract
The aim of this study was to explore the use of perinatal ketamine to see if it can be used for the reduction of postpartum depression (PPD) following cesarean section (C-section). PubMed, Cochrane, and Web of Science were the primary databases used for this review. Search terms used on January 5, 2024 incorporated "ketamine," "C-section," "postpartum depression," and related synonyms. The criteria for inclusion centered on studies published between January 1, 2008 and January 5, 2024. The final selection of articles was screened based on extraction criteria leaving eight randomized control trials in the final review. The selected data from the studies incorporated sample characteristics, study and population characteristics, and quantitative analyses covering Edinburgh Postpartum Depression Scale (EPDS) scores and depression rates. The Risk of Bias assessment was utilized to gain a deeper understanding of the quality of methodology used by the research studies. The review showed that ketamine can reduce the symptoms of PPD in mothers who have recently undergone C-sections. Some studies showed decreased EPDS scores following the administration of ketamine while two studies also reported no significant differences in PPD following ketamine administration in C-section patients. For example, Ma et al. found that the EPDS score at postpartum day 4 was significantly lower in the ketamine group compared with the control group (
Recommended Citation
Thompson, Jaylyn; Lo, David F; Foschini, Alexis; and Sundaresh, Suvan, "Exploring Perinatal Ketamine for Postpartum Depression Following Cesarean Section: A Systematic Review" (2024). Rowan-Virtua School of Osteopathic Medicine Departmental Research. 221.
https://rdw.rowan.edu/som_facpub/221
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Published Citation
Thompson J, Lo DF, Foschini A, Sundaresh S. Exploring perinatal ketamine for postpartum depression following cesarean section: A systematic review. PCN Rep. 2024 Aug 29;3(3):e70004. doi: 10.1002/pcn5.70004. PMID: 39219739; PMCID: PMC11362499.
Included in
Female Urogenital Diseases and Pregnancy Complications Commons, Obstetrics and Gynecology Commons, Organic Chemicals Commons, Pathological Conditions, Signs and Symptoms Commons, Pharmaceutical Preparations Commons, Psychiatric and Mental Health Commons, Psychiatry Commons, Therapeutics Commons, Women's Health Commons
