Date of Presentation

5-6-2021 12:00 AM

College

School of Osteopathic Medicine

Poster Abstract

Prostate cancer is the second leading cause of cancer death in men after lung cancer. The most common site of prostate metastasis is bone (84%), lymph node (10.6%), liver (10.2%), and thorax (9.1%), with 18.4% to multiple metastatic sites [1]. Prostate metastasis to the brain is rare, with less than 1% documented cases from M.D. Anderson Cancer Center [2]. It is estimated that 1%-6% of prostate cancer metastasis is found in post mortem examination [3]. Parenchymal brain metastasis has a mean survival of 9.2 months after discovery of brain metastasis [4]. Acute neurological symptoms of metastatic prostate cancer are observed with metastasis to the lumbar spine that impinge the spinal cord due to bony lesions. Symptoms of spinal cord compression, urinary retention, and hematuria are commonly seen. Conversely, meningioma is a slow growing, non-infiltrative tumor that commonly presents with headaches, seizures, and focal neurologic deficits depending on location [5]. Prostate cancer is often diagnosed with neurological symptoms along with increasing prostate specific antigen. Metastatic prostate cancer presenting with headaches with normal levels of PSA is a rare presentation. We report a 68-year-old male who presented to the emergency department with a primary complaint of headache and falls that was initially diagnosed as meningioma with MRI and intraoperative frozen section that was later confirmed to be metastatic adenocarcinoma of the prostate on pathology.

Keywords

Prostatic Neoplasms, prostate cancer, Neoplasm Metastasis, Meningioma

Disciplines

Male Urogenital Diseases | Medicine and Health Sciences | Neoplasms | Neurology | Oncology | Urology

Document Type

Poster

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May 6th, 12:00 AM

Metastatic Adenocarcinoma of the Prostate to the Brain Initially Diagnosed as Meningioma by Craniotomy: A Case Report

Prostate cancer is the second leading cause of cancer death in men after lung cancer. The most common site of prostate metastasis is bone (84%), lymph node (10.6%), liver (10.2%), and thorax (9.1%), with 18.4% to multiple metastatic sites [1]. Prostate metastasis to the brain is rare, with less than 1% documented cases from M.D. Anderson Cancer Center [2]. It is estimated that 1%-6% of prostate cancer metastasis is found in post mortem examination [3]. Parenchymal brain metastasis has a mean survival of 9.2 months after discovery of brain metastasis [4]. Acute neurological symptoms of metastatic prostate cancer are observed with metastasis to the lumbar spine that impinge the spinal cord due to bony lesions. Symptoms of spinal cord compression, urinary retention, and hematuria are commonly seen. Conversely, meningioma is a slow growing, non-infiltrative tumor that commonly presents with headaches, seizures, and focal neurologic deficits depending on location [5]. Prostate cancer is often diagnosed with neurological symptoms along with increasing prostate specific antigen. Metastatic prostate cancer presenting with headaches with normal levels of PSA is a rare presentation. We report a 68-year-old male who presented to the emergency department with a primary complaint of headache and falls that was initially diagnosed as meningioma with MRI and intraoperative frozen section that was later confirmed to be metastatic adenocarcinoma of the prostate on pathology.

 

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