Date of Presentation
5-5-2022 12:00 AM
College
School of Osteopathic Medicine
Poster Abstract
Liposarcoma (LS), a malignant tumor of adipose origin, is the most common soft tissue sarcoma (STS), and can develop within any soft tissue. It rarely occurs in the paratesticular region, and accounts for 3-7% of spermatic cord tumors. Dedifferentiated liposarcoma (DDLS) and well-differentiated liposarcoma (WDLS) account for two of the five subtypes of LS, with dedifferentiation occurring in 20% of cases. There have been 66 cases of DDLS of the spermatic cord reported to date, but none present with a 22/22q trisomy without the fusion or rearrangement that commonly produces these aggressive tumors.
Accurate diagnosis of LS of the spermatic cord is difficult but imperative for effective treatment. Misdiagnosis leads to ineffective management and poor outcomes, as seen in this case. This is the first reported case of DDLS showing 22/22q trisomy without fusion or rearrangement, and though its clinical significance is unclear, the complications arising from this spermatic cord LS were severe with significant implications for nearby anatomical structures. As this tumor’s aggressive features demonstrated the potential for requiring emergent treatment, a review of the literature surrounding management of DDLS of the spermatic cord with advanced disease at time of presentation was found to be lacking and management poorly defined. We hope that understanding malignant changes in tumors like the one presented in this case will help guide therapies currently in development that will take advantage of specific biological targets implicated in DDLS.
Keywords
Liposarcoma, Spermatic Cord, Case Reports
Disciplines
Diagnosis | Emergency Medicine | Male Urogenital Diseases | Medicine and Health Sciences | Neoplasms | Oncology | Urogenital System
Document Type
Poster
Included in
Diagnosis Commons, Emergency Medicine Commons, Male Urogenital Diseases Commons, Neoplasms Commons, Oncology Commons, Urogenital System Commons
Management of Late-Stage Ewingoid Dedifferentiated Liposarcoma of the Spermatic Cord with Emergent Complications: A Case Report
Liposarcoma (LS), a malignant tumor of adipose origin, is the most common soft tissue sarcoma (STS), and can develop within any soft tissue. It rarely occurs in the paratesticular region, and accounts for 3-7% of spermatic cord tumors. Dedifferentiated liposarcoma (DDLS) and well-differentiated liposarcoma (WDLS) account for two of the five subtypes of LS, with dedifferentiation occurring in 20% of cases. There have been 66 cases of DDLS of the spermatic cord reported to date, but none present with a 22/22q trisomy without the fusion or rearrangement that commonly produces these aggressive tumors.
Accurate diagnosis of LS of the spermatic cord is difficult but imperative for effective treatment. Misdiagnosis leads to ineffective management and poor outcomes, as seen in this case. This is the first reported case of DDLS showing 22/22q trisomy without fusion or rearrangement, and though its clinical significance is unclear, the complications arising from this spermatic cord LS were severe with significant implications for nearby anatomical structures. As this tumor’s aggressive features demonstrated the potential for requiring emergent treatment, a review of the literature surrounding management of DDLS of the spermatic cord with advanced disease at time of presentation was found to be lacking and management poorly defined. We hope that understanding malignant changes in tumors like the one presented in this case will help guide therapies currently in development that will take advantage of specific biological targets implicated in DDLS.