Date of Presentation
5-2-2024 12:00 AM
College
Rowan-Virtua School of Osteopathic Medicine
Poster Abstract
Saccharomyces boulardii (SB), a budding yeast, within the Saccharomyces genus. It commonly used as a probiotic that has been isolated from lychee and mangosteen fruit. S. boulardii is not known to acquire resistant genes and does not last in the intestine after 3-5 days of discontinuing the ingestion. The clinical efficacy of this probiotic yeast is known to improve various diarrhea such as pediatric diarrhea, antibiotic-associated diarrhea, acute diarrhea, and traveler’s diarrhea. Additionally, when used as an adjuvant to treatment for Helicobacter pylori and Clostridium difficile infections, it improves bacterial eradication, prevents relapse, reduces adverse reactions and treatment-associated diarrhea.
Several animal studies have shown that Saccharomyces boulardii can alleviate certain psychological and behavioral conditions through the brain-gut axis and modulate gut microbiome composition. There is bidirectional communication between the brain and gut which is carried out by various pathways like neuronal, endocrine, metabolic and immune. Alterations to composition and function of the microbiota are related to many stress related psychiatric disorders. This is evident in Irritable bowel syndrome (IBS), a gut-brain axis disorder that shares high levels of psychiatric comorbidities including anxiety and depression. The mechanism of how this happens is still unclear; however many studies support the view that the gut brain axis is key link between certain gastrointestinal and psychiatric disorders. Individually these disorders also share similar pathophysiology for example changes in monoamine levels and inflammatory states.
Keywords
Gastrointestinal Microbiome, Gut Microbiome, Brain-Gut Axis, Probiotics, Saccharomyces boulardii
Disciplines
Alternative and Complementary Medicine | Digestive System Diseases | Fungi | Gastroenterology | Medicine and Health Sciences | Pathological Conditions, Signs and Symptoms | Psychiatry
Document Type
Poster
Included in
Alternative and Complementary Medicine Commons, Digestive System Diseases Commons, Fungi Commons, Gastroenterology Commons, Pathological Conditions, Signs and Symptoms Commons, Psychiatry Commons
Health Benefits of Saccharomyces boulardii as a Probiotic
Saccharomyces boulardii (SB), a budding yeast, within the Saccharomyces genus. It commonly used as a probiotic that has been isolated from lychee and mangosteen fruit. S. boulardii is not known to acquire resistant genes and does not last in the intestine after 3-5 days of discontinuing the ingestion. The clinical efficacy of this probiotic yeast is known to improve various diarrhea such as pediatric diarrhea, antibiotic-associated diarrhea, acute diarrhea, and traveler’s diarrhea. Additionally, when used as an adjuvant to treatment for Helicobacter pylori and Clostridium difficile infections, it improves bacterial eradication, prevents relapse, reduces adverse reactions and treatment-associated diarrhea.
Several animal studies have shown that Saccharomyces boulardii can alleviate certain psychological and behavioral conditions through the brain-gut axis and modulate gut microbiome composition. There is bidirectional communication between the brain and gut which is carried out by various pathways like neuronal, endocrine, metabolic and immune. Alterations to composition and function of the microbiota are related to many stress related psychiatric disorders. This is evident in Irritable bowel syndrome (IBS), a gut-brain axis disorder that shares high levels of psychiatric comorbidities including anxiety and depression. The mechanism of how this happens is still unclear; however many studies support the view that the gut brain axis is key link between certain gastrointestinal and psychiatric disorders. Individually these disorders also share similar pathophysiology for example changes in monoamine levels and inflammatory states.