Date of Presentation
5-2-2024 12:00 AM
College
Rowan-Virtua School of Osteopathic Medicine
Poster Abstract
Aims: This review aims to expand upon previous research examining change in gastrointestinal microbiota before and after cholecystectomy.
Methods: A systematic review, combined with a pooled analysis, was conducted to assess gut microbiota dysbiosis post-cholecystectomy, utilizing 71 articles retrieved from 3 databases, with 13 undergoing full-text appraisal. The publication dates ranged from 2018 to 2023.
Results: Results suggested a greater degree of microbiota alteration in symptomatic post-cholecystectomy patients, characterized by a decrease in the Firmicutes/Bacteroidetes ratio, Bifidobacterium and Lactococcus, alongside increased levels of harmful microbiota such as Prevotella, Sutterella, Proteobacteria, Verrucomicrobia, Blautia obeum, and Veillonella species. Interestingly, an increase in Firmicutes and Bacteroidetes was observed in two different studies.
Conclusion: the research consistently shows dysbiosis in gut microbiota following cholecystectomy with potential implications for gastrointestinal and overall health. These findings emphasize the need for future research in maintaining a balanced gut microbiota when managing post-cholecystectomy patients with dysbiosis.
Keywords
post-cholecystectomy, cholecystectomy, gut microbiome, Gastrointestinal Microbiome
Disciplines
Bacteria | Digestive System | Digestive System Diseases | Gastroenterology | Medicine and Health Sciences
Document Type
Poster
Included in
Bacteria Commons, Digestive System Commons, Digestive System Diseases Commons, Gastroenterology Commons
Gut Microbiota Changes After Cholecystectomy: Unraveling the Microbial Mysteries - A Systematic Review
Aims: This review aims to expand upon previous research examining change in gastrointestinal microbiota before and after cholecystectomy.
Methods: A systematic review, combined with a pooled analysis, was conducted to assess gut microbiota dysbiosis post-cholecystectomy, utilizing 71 articles retrieved from 3 databases, with 13 undergoing full-text appraisal. The publication dates ranged from 2018 to 2023.
Results: Results suggested a greater degree of microbiota alteration in symptomatic post-cholecystectomy patients, characterized by a decrease in the Firmicutes/Bacteroidetes ratio, Bifidobacterium and Lactococcus, alongside increased levels of harmful microbiota such as Prevotella, Sutterella, Proteobacteria, Verrucomicrobia, Blautia obeum, and Veillonella species. Interestingly, an increase in Firmicutes and Bacteroidetes was observed in two different studies.
Conclusion: the research consistently shows dysbiosis in gut microbiota following cholecystectomy with potential implications for gastrointestinal and overall health. These findings emphasize the need for future research in maintaining a balanced gut microbiota when managing post-cholecystectomy patients with dysbiosis.