Document Type
Article
Version Deposited
Published Version
Publication Date
10-11-2021
Publication Title
Pharmaceutics
DOI
https://doi.org/10.3390/pharmaceutics13101657
Abstract
Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug-body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.
Recommended Citation
Cecen, Berivan, Christina Karavasili, Mubashir Nazir, Anant Bhusal, Elvan Dogan, Fatemeh Shahriyari, Sedef Tamburaci, Melda Buyukoz, Leyla Didem Kozaci, and Amir K. Miri. 2021. "Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives" Pharmaceutics 13, no. 10: 1657. https://doi.org/10.3390/pharmaceutics13101657
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.