Date Approved

6-16-2020

Embargo Period

6-17-2020

Document Type

Thesis

Degree Name

M.S. Chemical Engineering

Department

Chemical Engineering

College

Henry M. Rowan College of Engineering

Advisor

Noshadi, Iman

Committee Member 1

Sharifi, Nourouddin

Committee Member 2

Soroush, Fariborz

Subject(s)

Biomedical materials; Biocompatibility

Disciplines

Biomedical Engineering and Bioengineering | Chemical Engineering | Materials Science and Engineering

Abstract

Health issues have always been one of humankind's biggest challenges. Over the last century, there has been significant and monumental progress in health and biomedical science, with the end goal of alleviating and eliminating illnesses and ailments. For developing biomedical devices, polymers and elastomers group among other types of biomaterials have been highlighted to be used due to high flexibility, stability, biocompatibility, and mechanical and rheological characteristics. In this work, the characterization of acrylated poly glycerol_sebacate (PGSA) polymer conjugated with bio ionic liquid (BIL) was investigated. Results showed high biocompatibility, high printability with tunable mechanical, adhesive, and conductivity properties. For example, without BIL, the conductivity is less than 0.05x10^-5 S/m, and it shows growth to more than 0.2x10^-5 S/m for 60%PGSA/40% BIL. The swelling ratio is reported 70(%w/w) for 50% PGSA/50% BIL sample compared to 20% in the control sample. Biocompatibility of this composition in_vitro and in_vivo has been investigated by using C2C12 cell lines for in_vitro conditions and a rat animal model in_vivo. These results validate the biocompatibility of PGSA/BIL with 98% cell viability and its potential in cell adhesion, growth, and proliferation. The results show the potential of PGSA for various biomedical applications such as bioelectronics, sensors, and regenerative medicine.

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