Document Type
Article
Version Deposited
Published Version
Publication Date
6-5-2019
Publication Title
G3 Genes - Genomes - Genetics (Bethesda)
DOI
10.1534/g3.119.400077
Abstract
The transcriptional changes that occur in response to oxidative stress help direct the decision to maintain cell viability or enter a cell death pathway. Cyclin C-Cdk8 is a conserved kinase that associates with the RNA polymerase II Mediator complex that stimulates or represses transcription depending on the locus. In response to oxidative stress, cyclin C, but not Cdk8, displays partial translocation into the cytoplasm. These findings open the possibility that cyclin C relocalization is a regulatory mechanism governing oxidative stress-induced transcriptional changes. In the present study, the cyclin C-dependent transcriptome was determined and compared to transcriptional changes occurring in oxidatively stressed
Recommended Citation
Stieg DC, Chang KT, Cooper KF, Strich R. Cyclin C regulated oxidative stress responsive transcriptome in mus musculus embryonic fibroblasts. G3 Genes - Genomes - Genetics. 2019 Jun 5;9(6):1901-1908. doi: 10.1534/g3.119.400077. PMID: 31036676. PMCID: PMC6553531.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Included in
Animal Experimentation and Research Commons, Genetic Phenomena Commons, Laboratory and Basic Science Research Commons, Medical Cell Biology Commons, Medical Genetics Commons
