Document Type

Article

Version Deposited

Published Version

Publication Date

6-5-2019

Publication Title

G3 Genes - Genomes - Genetics (Bethesda)

DOI

10.1534/g3.119.400077

Abstract

The transcriptional changes that occur in response to oxidative stress help direct the decision to maintain cell viability or enter a cell death pathway. Cyclin C-Cdk8 is a conserved kinase that associates with the RNA polymerase II Mediator complex that stimulates or represses transcription depending on the locus. In response to oxidative stress, cyclin C, but not Cdk8, displays partial translocation into the cytoplasm. These findings open the possibility that cyclin C relocalization is a regulatory mechanism governing oxidative stress-induced transcriptional changes. In the present study, the cyclin C-dependent transcriptome was determined and compared to transcriptional changes occurring in oxidatively stressed

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Published Citation

Stieg DC, Chang KT, Cooper KF, Strich R. Cyclin C regulated oxidative stress responsive transcriptome in mus musculus embryonic fibroblasts. G3 Genes - Genomes - Genetics. 2019 Jun 5;9(6):1901-1908. doi: 10.1534/g3.119.400077. PMID: 31036676. PMCID: PMC6553531.

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