Document Type

Poster

Version Deposited

Published Version

Publication Date

12-15-2017

Publication Title

Molecular Biology of the Cell

Conference Name

2017 ASCB/EMBO Annual Meeting

DOI

10.1091/mbc.E17-10-0618

Abstract

In response to stress, the yeast1 and mammalian2 cyclin C translocate from the nucleus to the cytoplasm, where it associates with the GTPase Drp1/Dnm1 to drive mitochondrial fragmentation and apoptosis. Therefore, the decision to release cyclin C represents a key life or death decision. In unstressed cells, the cyclin C‐Cdk8 kinase regulates transcription by associating with the Mediator of RNA polymerase II. We previously reported that the Mediator component Med13 anchors cyclin C in the nucleus3. Loss of Med13 function leads to constitutive cytoplasmic localization of cyclin C, resulting in fragmented mitochondria, hypersensitivity to stress and mitochondrial dysfunction due to loss of mtDNA. Recently we showed that this molecular switch operates in a two-step process.

Comments

Complete conference abstracts available as "Supplemental Material" at https://www.molbiolcell.org/doi/full/10.1091/mbc.E17-10-0618

[A]uthors are permitted to post the MBoC PDF of their articles (and/or supplemental material) on their personal websites or in an online institutional repository provided there appears always the proper citation of the manuscript in MBoC and a link to the original publication of the manuscript in MBoC.

Creative Commons License

Creative Commons Attribution-Noncommercial-Share Alike 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

Published Citation

Stieg DC, Willis SD, Scuorzo J, Song M, Ganesan V, Strich R, Cooper KF. The role of MAPK and SCF in the destruction of Med13 in cyclin C mediated cell death [Conference Abstract P2437, p. Monday 359-360]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.

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