Document Type

Poster

Version Deposited

Published Version

Publication Date

12-15-2017

Publication Title

Molecular Biology of the Cell

Conference Name

2017 ASCB/EMBO Annual Meeting

DOI

10.1091/mbc.E17-10-0618

Abstract

In response to stress, the yeast1 and mammalian2 cyclin C translocate from the nucleus to the cytoplasm, where it associates with the GTPase Drp1/Dnm1 to drive mitochondrial fragmentation and apoptosis. Therefore, the decision to release cyclin C represents a key life or death decision. In unstressed cells, the cyclin C‐Cdk8 kinase regulates transcription by associating with the Mediator of RNA polymerase II. We previously reported that the Mediator component Med13 anchors cyclin C in the nucleus3. Loss of Med13 function leads to constitutive cytoplasmic localization of cyclin C, resulting in fragmented mitochondria, hypersensitivity to stress and mitochondrial dysfunction due to loss of mtDNA. Recently we showed that this molecular switch operates in a two-step process.

Comments

Complete conference abstracts available as "Supplemental Material" at https://www.molbiolcell.org/doi/full/10.1091/mbc.E17-10-0618

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Creative Commons License

Creative Commons Attribution-Noncommercial-Share Alike 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

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