Document Type


Version Deposited

Published Version

Publication Date


Publication Title

Molecular Biology of the Cell

Conference Name

2017 ASCB/EMBO Annual Meeting




Eukaryotic cells take cues from their environment and interpret them to enact a response. External stresses can produce a decision between adjusting to behaviors which promote surviving the stress, or enacting a cell death program. The decision to undergo programmed cell death (PCD) is controlled by a complex interaction between nuclear and mitochondrial signals. The mitochondria are highly dynamic organelles that constantly undergo fission and fusion. However, a dramatic shift in mitochondrial morphology toward fission occurs early in the PCD process. We have identified the transcription factor cyclin C as the biochemical trigger for stress‐induced mitochondrial hyper‐fragmentation in yeast (Cooper et al., 2014 Dev. Cell) and mammalian (Wang et al., 2015, MCB) cells.


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