Molecular Biology of the Cell
2017 ASCB/EMBO Annual Meeting
Eukaryotic cells take cues from their environment and interpret them to enact a response. External stresses can produce a decision between adjusting to behaviors which promote surviving the stress, or enacting a cell death program. The decision to undergo programmed cell death (PCD) is controlled by a complex interaction between nuclear and mitochondrial signals. The mitochondria are highly dynamic organelles that constantly undergo fission and fusion. However, a dramatic shift in mitochondrial morphology toward fission occurs early in the PCD process. We have identified the transcription factor cyclin C as the biochemical trigger for stress‐induced mitochondrial hyper‐fragmentation in yeast (Cooper et al., 2014 Dev. Cell) and mammalian (Wang et al., 2015, MCB) cells.
Smethurst, Daniel G J; Cooper, Katrina F; and Strich, Randy, "Translocation of Cyclin C During Oxidative Stress Is Regulated by Interactions with Multiple Trafficking Proteins" (2017). School of Osteopathic Medicine Faculty Scholarship. 126.
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Smethurst DG, Cooper KF, Strich R. Translocation of cyclin C during oxidative stress is regulated by interactions with multiple trafficking proteins [Conference Abstract P3264; Tuesday 345-346]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.