Molecular Biology of the Cell
2017 ASCB/EMBO Annual Meeting
Eukaryotic cells take cues from their environment and interpret them to enact a response. External stresses can produce a decision between adjusting to behaviors which promote surviving the stress, or enacting a cell death program. The decision to undergo programmed cell death (PCD) is controlled by a complex interaction between nuclear and mitochondrial signals. The mitochondria are highly dynamic organelles that constantly undergo fission and fusion. However, a dramatic shift in mitochondrial morphology toward fission occurs early in the PCD process. We have identified the transcription factor cyclin C as the biochemical trigger for stress‐induced mitochondrial hyper‐fragmentation in yeast (Cooper et al., 2014 Dev. Cell) and mammalian (Wang et al., 2015, MCB) cells.
Smethurst DG, Cooper KF, Strich R. Translocation of cyclin C during oxidative stress is regulated by interactions with multiple trafficking proteins [Conference Abstract P3264; Tuesday 345-346]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.
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