Document Type

Poster

Version Deposited

Published Version

Publication Date

12-15-2017

Publication Title

Molecular Biology of the Cell

Conference Name

2017 ASCB/EMBO Annual Meeting

DOI

10.1091/mbc.E17-10-0618

Abstract

Eukaryotic cells take cues from their environment and interpret them to enact a response. External stresses can produce a decision between adjusting to behaviors which promote surviving the stress, or enacting a cell death program. The decision to undergo programmed cell death (PCD) is controlled by a complex interaction between nuclear and mitochondrial signals. The mitochondria are highly dynamic organelles that constantly undergo fission and fusion. However, a dramatic shift in mitochondrial morphology toward fission occurs early in the PCD process. We have identified the transcription factor cyclin C as the biochemical trigger for stress‐induced mitochondrial hyper‐fragmentation in yeast (Cooper et al., 2014 Dev. Cell) and mammalian (Wang et al., 2015, MCB) cells.

Comments

Complete conference abstracts available as "Supplemental Material" at https://www.molbiolcell.org/doi/full/10.1091/mbc.E17-10-0618

[A]uthors are permitted to post the MBoC PDF of their articles (and/or supplemental material) on their personal websites or in an online institutional repository provided there appears always the proper citation of the manuscript in MBoC and a link to the original publication of the manuscript in MBoC.

Creative Commons License

Creative Commons Attribution-Noncommercial-Share Alike 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

Published Citation

Smethurst DG, Cooper KF, Strich R. Translocation of cyclin C during oxidative stress is regulated by interactions with multiple trafficking proteins [Conference Abstract P3264; Tuesday 345-346]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.

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