Document Type

Article

Version Deposited

Accepted for publication (PostPrint)

Publication Date

1-1-2018

Publication Title

The Journal of Neuropsychiatry and Clinical Neurosciences

DOI

10.1176/appi.neuropsych.17080173

Abstract

Up to 90% of individuals with Huntington's disease (HD)-a progressive, inherited neurodegenerative disorder-experience apathy. Apathy is particularly debilitating because it is marked by a reduction in goal-directed behaviors, including self-care, social interactions, and mobility. The objective of this study was to examine relationships between variables of apathy, functional status, physical function, cognitive function, behavioral status/emotional function, and health-related quality of life. Clinician-rated measures of physical, cognitive, and behavioral function, including one clinician-rated item on apathy, and self-reported measures of physical function, health-related quality of life, and emotional, cognitive, and social function were collected in a single session from 487 persons with the HD mutation (prodromal, N=193; early-stage manifest, N=186; late-stage manifest, N=108). Multiple linear regression models were used to examine which outcomes best predicted clinician-rated apathy after controlling for disease stage. Greater apathy related to less independence, increased motor impairment, and more clinician-rated behavioral problems (i.e., anger, irritability, depression). Similarly, poorer self-reported health-related quality of life; greater chorea; greater upper- and lower-extremity dysfunction; greater speech and swallowing dysfunction; worse anxiety, depression, and behavioral dyscontrol; worse cognitive function; and less satisfaction with social roles related to greater apathy. In conclusion, apathy related to physical, cognitive, and behavioral dysfunction across disease stages. Future work should explore whether clinical interventions targeting different functional domains may have the potential to reduce apathy in this patient population.

Comments

© American Psychiatric Association Publishing

American Psychiatric Association Publishing…acknowledges authors’ right to deposit their peer-reviewed Accepted Manuscript…in public or institutional repositories for public release as mandated by their funding agency. These repositories will make the deposited manuscript freely available to the public 12 months after publication in an American Psychiatric Association Publishing journal.

Published Citation

Fritz NE, Boileau NR, Stout JC, Ready R, Perlmutter JS, Paulsen JS, Quaid K, Barton S, McCormack MK, Perlman SL, Carlozzi NE. Relationships among apathy, health-related quality of life, and function in Huntington’s disease. Journal of Neuropsychiatry and Clinical Neurosciences. 2018 Jul;30(3):194-201. Epub 2018 Mar 21. doi: 10.1176/appi.neuropsych.17080173. PMID: 29558861. PMCID: PMC608124.

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