Document Type

Article

Version Deposited

Accepted for publication (PostPrint)

Publication Date

1-1-2018

Publication Title

Journal of Huntington's Disease

DOI

10.3233/JHD-180299

Abstract

BACKGROUND: Huntington disease (HD) is associated with increased risk of suicide.

OBJECTIVE: This study compares suicide ideation in HD to the general population, assesses factors associated with increased prevalence of suicidal thoughts, and compares clinician-rated to self-reported assessments of suicidal ideation.

METHODS: We examined 496 participants with premanifest or manifest HD. Clinician-rated suicidal ideation was measured using the Problem Behaviors Assessment - short form. Self-reported ideation was measured using two items from the HDQLIFE Concern with Death and Dying item bank. Independent sample t-tests were conducted to compare the prevalence of suicidal thoughts between our HD sample and the U.S.

POPULATION: Logistic regression analyses were used to determine characteristics associated with higher odds of clinically significant suicidal ideation. Kappa agreement coefficients were calculated to evaluate concurrence between clinician-rated and self-reported assessments.

RESULTS: Our sample had a significantly higher occurrence of suicidal ideation (19.76%) and suicidal plans (2.1%) than the general population (p < 0.0001). Odds of clinically significant suicidal ideation were 6.8 times higher in females (p = 0.04) on the clinician measure, and Hispanic/Latinos had 10.9 times higher odds than non-Hispanics (p = 0.025) on the self-report measure. Clinician-rated assessment had fair agreement (k = 0.2-0.4) with self-reported assessments, except in early stage HD where there was no overlap in the identification of participants with clinically significant suicidal ideation.

DISCUSSION: Assessment for suicidal ideation and clinically significant suicidal thoughts in HD with a multimodal approach that includes clinician-rated and self-report measures is critical at all stages of the disease.

Comments

The final publication is available at IOS Press through https://content.iospress.com/articles/journal-of-huntingtons-disease/jhd180299

Published Citation

Wesson M, Boileau NR, S Perlmutter JS, Paulsen J, Barton SK, McCormack MK, Carlozzi NE. Suicidal ideation assessment in individuals with premanifest and manifest Huntington disease. Journal of Huntington’s Disease. 2018 Jul 27. doi: 10.3233/JHD-180299. PMID: 30056431. PMCID: PMC6108173.

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