Molecular Biology of the Cell
2017 ASCB Annual Meeting
Living organisms are constantly exposed to a variety of environmental and internal stressors tha tare detrimental to their cellular physiology and viability. One such condition, oxidativestress, is caused by abnormal amounts of Reactive Oxygen Species (ROS) that can lead to damage to proteins, nucleic acids, and lipids. Although the mechanisms to neutralize ROS have been widely studied, the understanding of ROS‐mediated signaling for these mechanisms is rather incomplete and sparse. We have uncovered a previously undescribed phenomenon of yeast ribosomes to respond to elevated levels of ROS through a specific endonucleolytic cleavage of the 25S rRNA in the c‐loop of the expansion segment 7 (ES7c) regions.
Zinskie, Jessica A; Shedlovskiy, Daniel; Gardner, Ethan; Pestov, Dimitri G; and Shcherbik, Natalia, "Modification of the Ribosome as Part of the Adaptive Response to Oxidative Stress in Yeast" (2017). School of Osteopathic Medicine Faculty Scholarship. 149.
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Zinskie JA, Shedlovskiy D, Gardner E, Pestov D, Shcherbik N. Modification of the ribosome as part of the adaptive response to oxidative stress in yeast [Conference Abstract P2552]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.
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