Journal of the International Neuropsychological Society : JINS
OBJECTIVE: To determine whether the DCTclock can detect differences across groups of patients seen in the memory clinic for suspected dementia.
METHOD: Patients (n = 123) were classified into the following groups: cognitively normal (CN), subtle cognitive impairment (SbCI), amnestic cognitive impairment (aMCI), and mixed/dysexecutive cognitive impairment (mx/dysMCI). Nine outcome variables included a combined command/copy total score and four command and four copy indices measuring drawing efficiency, simple/complex motor operations, information processing speed, and spatial reasoning.
RESULTS: Total combined command/copy score distinguished between groups in all comparisons with medium to large effects. The mx/dysMCI group had the lowest total combined command/copy scores out of all groups. The mx/dysMCI group scored lower than the CN group on all command indices (
CONCLUSIONS: These results suggest that DCTclock command/copy parameters can dissociate CN, SbCI, and MCI subtypes. The larger effect sizes for command clock indices suggest these metrics are sensitive in detecting early cognitive decline. Additional research with a larger sample is warranted.
Matusz, Emily F.; Price, Catherine C.; Lamar, Melissa; Swenson, Rod; Au, Rhoda; Emrani, Sheina; Wasserman, Victor; Libon, David J; and Thompson, Louisa I., "Dissociating Statistically Determined Normal Cognitive Abilities and Mild Cognitive Impairment Subtypes with DCTclock." (2023). Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship. 171.
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Matusz EF, Price CC, Lamar M, et al. Dissociating Statistically Determined Normal Cognitive Abilities and Mild Cognitive Impairment Subtypes with DCTclock. Journal of the International Neuropsychological Society. 2023;29(2):148-158. doi:10.1017/S1355617722000091