Journal of Neuroimmunology
The goal of this preliminary proof-of-concept study was to use human protein microarrays to identify blood-based autoantibody biomarkers capable of diagnosing multiple sclerosis (MS). Using sera from 112 subjects, including 51 MS subjects, autoantibody biomarkers effectively differentiated MS subjects from age- and gender-matched normal and breast cancer controls with 95.0% and 100% overall accuracy, but not from subjects with Parkinson's disease. Autoantibody biomarkers were also useful in distinguishing subjects with the relapsing-remitting form of MS from those with the secondary progressive subtype. These results demonstrate that autoantibodies can be used as noninvasive blood-based biomarkers for the detection and subtyping of MS
DeMarshall, Cassandra; Goldwaser, Eric; Sarkar, Abhirup; Godsey, George; Acharya, Nimish; Thayasivam, Umashanger; Belinka, Benjamin; and Nagele, Robert, "Autoantibodies as Diagnostic Biomarkers for the Detection and Subtyping of Multiple Sclerosis" (2017). School of Osteopathic Medicine Faculty Scholarship. 59.
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DeMarshall C, Goldwaser EL, Sarkar A, Godsey GA, Acharya NK, Thayasivam U, Belinka BA, Nagele RG. Autoantibodies as Diagnostic Biomarkers for the Detection and Subtyping of Multiple Sclerosis. J Neuroimmunol. 2017 Aug 15;309:51-57. Epub 2017 May 19. doi: 10.1016/j.jneuroim.2017.05.010. PMID: 28601288.