A Complex Molecular Switch Directs Stress-Induced Cyclin C Nuclear Release Through SCFGrr1-Mediated Degradation of Med13.
Molecular Biology of the Cell
In response to oxidative stress, cells decide whether to mount a survival or cell death response. The conserved cyclin C and its kinase partner Cdk8 play a key role in this decision. Both are members of the Cdk8 kinase module, which, with Med12 and Med13, associate with the core mediator complex of RNA polymerase II. In
Stieg DC, Willis SD, Ganesan V, Ong KL, Scuorzo J, Song M, Grose J, Strich R, Cooper KF. A complex molecular switch directs stress-induced cyclin C nuclear release through SCFGrr1-mediated degradation of Med13. Mol Biol Cell. 2018 Feb 1;29(3):363-375.. Epub 2017 Dec 6. doi: 10.1091/mbc.E17-08-0493. PMID: 29212878. PMCID: PMC5996960.
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