Maternal Diet, C-Reactive Protein, and the Outcome of Pregnancy

Theresa Scholl, Rowan University School of Osteopathic Medicine
Xinhua Chen, Rowan University School of Osteopathic Medicine
Gary Goldberg, Rowan University School of Osteopathic Medicine
P. Khusial, Rowan University School of Osteopathic Medicine
T. Stein, Rowan University School of Osteopathic Medicine

Abstract

OBJECTIVE: To examine the association of high-sensitivity C-reactive protein (hsCRP), a systemic biomarker for the inflammatory process at entry to care, with pregnancy-induced hypertension/preeclampsia, adverse outcomes of pregnancy, and the maternal diet. DESIGN: Random sample (N = 520) with normal glucose tolerance from a large prospective cohort study of urban, low income, minority gravidae. RESULTS: During pregnancy, the highest tertile of hsCRP (range, 7.06-137.41 mg/L) was associated with significantly increased risks for early preterm delivery ( CONCLUSIONS: High hsCRP is a diet-related biomarker for serious complications and poor outcome in lean women with normal glucose tolerance.