Mechanisms of Environmental Chemicals that Enable the Cancer Hallmark of Evasion of Growth Suppression
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As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
Nahta, Rita; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Amedei, Amedeo; Andrade-Vieira, Rafaela; Bay, Sarah; Brown, Dustin; Calaf, Gloria; Calaf, Gloria; Castellino, Robert; Cohen-Solal, Karine; Colacci, Anna; Cruickshanks, Nichola; Dent, Paul; Di Fiore, Riccardo; Forte, Stefano; Goldberg, Gary; Hamid, Roslida; Krishnan, Harini; Laird, Dale; Lasfar, Ahmed; Marignani, Paola; Memeo, Lorenzo; Mondello, Chiara; Naus, Christian; Ponce-Cusi, Richard; Raju, Jayadev; Roy, Debasish; Roy, Rabindra; Ryan, Elizabeth; Salem, Hosni; Scovassi, A.Ivana; Singh, Neetu; Vaccari, Monica; Vento, Renza; Vento, Renza; Vondráček, Jan; Wade, Mark; Woodrick, Jordan; and Bisson, William, "Mechanisms of Environmental Chemicals that Enable the Cancer Hallmark of Evasion of Growth Suppression" (2015). School of Osteopathic Medicine Faculty Scholarship. 78.
Nahta R, Al-Mulla F, Al-Temaimi R, Amedei A, Andrade-Vieira R, Bay SN, Brown DG, Calaf GM, Castellino RC, Cohen-Solal KA, Colacci A, Cruickshanks N, Dent P, Di Fiore R, Forte S, Goldberg GS, Hamid RA, Krishnan H, Laird DW, Lasfar A, Marignani PA, Memeo L, Mondello C, Naus CC, Ponce-Cusi R, Raju J, Roy D, Roy R, Ryan EP, Salem HK, Scovassi AI, Singh N, Vaccari M, Vento R, Vondráček J2, Wade M, Woodrick J, Bisson WH. Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis. 2015 Jun;36 Suppl 1:S2-18. doi: 10.1093/carcin/bgv028. PMID: 26106139. PMCID: PMC4565608.