Date of Presentation

5-3-2018 8:00 AM

College

School of Osteopathic Medicine

Poster Abstract

Myeloid sarcoma is a rare and aggressive tumor of myelogenous origin that uncommonly presents in the small bowel. Here we describe the case of a 29 year old male with a two week history of worsening abdominal pain associated with nausea and bilious vomiting. The patient displayed tenderness in the epigastric and periumbilical region with grossly normal lab values. On CT he was found to have a small bowel obstruction with a transition point in the pelvis. Exploration revealed a small bowel mass located approximately 12 cm from the ileocecal valve. Pathological analysis showed large malignant cells with a high mitotic rate that were positive for CD 45, CD43, CD34, CD117, and BCL2. Also, the tumor cells were shown to have KI67 positivity of >80%. The pathological analysis strongly supported the diagnosis of myeloid sarcoma. Given the patient's age, site of occurrence, and overall lack of previous studies on myeloid sarcoma this case is highly notable and recommended for review.

Keywords

sarcoma, myeloid, intestinal neoplasms

Disciplines

Digestive System Diseases | Medicine and Health Sciences | Neoplasms

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May 3rd, 8:00 AM

Myeloid Sarcoma: A Rare Cause of Small Bowel Obstruction

Myeloid sarcoma is a rare and aggressive tumor of myelogenous origin that uncommonly presents in the small bowel. Here we describe the case of a 29 year old male with a two week history of worsening abdominal pain associated with nausea and bilious vomiting. The patient displayed tenderness in the epigastric and periumbilical region with grossly normal lab values. On CT he was found to have a small bowel obstruction with a transition point in the pelvis. Exploration revealed a small bowel mass located approximately 12 cm from the ileocecal valve. Pathological analysis showed large malignant cells with a high mitotic rate that were positive for CD 45, CD43, CD34, CD117, and BCL2. Also, the tumor cells were shown to have KI67 positivity of >80%. The pathological analysis strongly supported the diagnosis of myeloid sarcoma. Given the patient's age, site of occurrence, and overall lack of previous studies on myeloid sarcoma this case is highly notable and recommended for review.

 

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