Document Type
Article
Version Deposited
Published Version
Publication Date
9-11-2020
Publication Title
International Journal of Nanomedicine
DOI
10.2147/IJN.S259724
Abstract
Purpose: Nucleic acid-based therapies are a promising therapeutic tool. The major obstacle in their clinical translation is their efficient delivery to the desired tissue. We developed a novel nanosized delivery system composed of conjugates of α-tocopherol, polyethyleneimine, and polyethylene glycol (TPP) to deliver nucleic acids.
Methods: We synthesized a panel of TPP molecules using different molecular weights of PEG and PEI and analyzed with various analytical approaches. The optimized version of TPP (TPP
Results: Through a panel of synthesized molecules, TPP
Conclusion: These results indicate that we successfully synthesized the TPP
Recommended Citation
Hossian AKMN, Jois SD, Jonnalagadda SC, & Mattheolabakis G. (2020) Nucleic Acid Delivery with α-Tocopherol-Polyethyleneimine-Polyethylene Glycol Nanocarrier System. International Journal of Nanomedicine. 2020;15:6689-6703 https://doi.org/10.2147/IJN.S259724
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Comments
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.