Date Approved

2-14-2018

Embargo Period

2-14-2018

Document Type

Thesis

Degree Name

MS Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Jonnalagadda, Subash

Committee Member 1

Perez, Lark

Committee Member 2

Vaden, Timothy

Keywords

Baylis-Hillman, Bio-Renewable, Polymers, Synthesis

Subject(s)

Biomass chemicals; Polymerization

Disciplines

Medicinal-Pharmaceutical Chemistry

Abstract

The focus of this project was to develop methodologies for the preparation of novel polymeric materials from bio-renewable sources. In order to complete this task we needed (a) unfettered access to bio-based materials and ways to convert them to value needed chemicals, as well as, (b) reaction protocols that would allow greater diversity during the synthesis of polymeric compounds so as to affect the properties of these materials.

Our research group has a background in converting plant-based materials like cellulose into value added chemicals employing catalytic reactions. The polymerization of these monomers was then conducted utilizing the Baylis-Hillman reaction. The resulting alcohol adduct obtained from this reaction allowed for various alterations on the polymer with relative ease. This chemical versatility of the Baylis-Hillman reaction offers tremendous potential toward the synthesis of an array of polymeric materials.

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