Date Approved

10-1-2024

Embargo Period

10-1-2024

Document Type

Thesis

Degree Name

Master of Science (M.S.) in Pharmaceutical Sciences

Department

Chemistry & Biochemistry

College

College of Science & Mathematics

Advisor

Lark Perez, Ph.D.

Committee Member 1

Subash Jonnalagadda, Ph.D.

Committee Member 2

Kandalam Ramanujachary, Ph.D.

Committee Member 3

Gustavo Moura-Letts, Ph.D.

Committee Member 4

Michael Law, Ph.D.

Keywords

Bacteria; Bioluminescence; Catalysis; Photoredox; Radicals

Subject(s)

Photochemistry--Industrial applications

Disciplines

Chemistry

Abstract

The bioluminescence-induced photoredox reaction (BIPR) is a novel methodology developed to overcome the limitations of photo-induced chemistry by initiating chemical work using bioluminescent Escherichia coli as a photon source. In industry, photochemistry is superseded by thermochemical reaction processes. Despite its massive potential, there are very few applications in industry for photochemistry. Unlike thermochemistry, reaction scale-ups are not as easy as simple dimensional increases in a reaction vessel due to the nature of light. This deficiency is seemingly overcome through the development of flow technologies; however, the overall yield of such methods remains incomparable with those utilizing thermochemistry. This thesis focuses on a reaction method we have developed to fulfill the requirements for an environmentally friendly, feasible reaction process that could potentially be scaled up in industry. Insights from the data collected provide a deeper understanding of the limitations, strengths, and forces that drive photochemistry that have been achieved via the proposed methodology described therein.

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