Date of Presentation
5-2-2024 12:00 AM
College
Rowan-Virtua School of Osteopathic Medicine
Poster Abstract
Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is considered the most advanced temporary life support which provides complete hemodynamic support in addition to gas exchange. There is limited data available on the impact of hyperlipidemia (HLD) on VA-ECMO patients. We sought to examine the national inpatient sample (NIS) database to describe in-hospital outcomes among these patients.
Methods: The NIS was searched for hospitalizations of adult VA-ECMO patients with and without a concomitant diagnosis of HLD for the years 2019 and 2020. The primary outcome was inpatient mortality.
Results: This study included 3,885 VA-ECMO patients, of which 1,082 (27.8%) patients had HLD. VA-ECMO patients with HLD had higher prevalence of hypertension (57.3% vs. 71.4%, p <0.001), and chronic kidney disease (26.3% vs. 17.0 %, p <0.001) compared to VA-ECMO patients without HLD. In-hospital mortality was higher among those with HLD (61.5 % vs. 45.5%, p <0.001). Multivariate regression showed that VA-ECMO patients with HLD had higher inpatient mortality (OR 1.371, 95% CI 1.332-1.410, p <0.001). On secondary analysis, patients had higher odds of having ventricular arrhythmia (OR 1.472, 95% CI 1.416-1.531, p <0.001), acute kidney failure (OR 1.394, 95% CI 1.359-1.429, p <0.001), intracranial hemorrhage (OR 1.157, 95% CI 1.099-1.219, p <0.001), DVT (OR 1.252, 95% CI 1.200-1.306, p < 0.001), and sepsis (OR 1.226, 95% CI 1.195-1.257, p <0.001) compared to VA-ECMO patients without HLD.
Conclusion: In this nationally representative population‐based retrospective cohort study, HLD was associated with higher mortality and worse outcomes among VA-ECMO patients.
Keywords
VA-ECMO, HLD, NIS, in-hospital outcomes, Extracorporeal Membrane Oxygenation, Treatment Outcome, National Inpatient Sample, Hospital Mortality
Disciplines
Cardiology | Cardiovascular Diseases | Critical Care | Medicine and Health Sciences | Nutritional and Metabolic Diseases | Pathological Conditions, Signs and Symptoms | Patient Safety | Therapeutics
Document Type
Poster
Included in
Cardiology Commons, Cardiovascular Diseases Commons, Critical Care Commons, Nutritional and Metabolic Diseases Commons, Pathological Conditions, Signs and Symptoms Commons, Patient Safety Commons, Therapeutics Commons
Clinical Outcomes for VA-ECMO Patients Associated with Hyperlipidemia: An Analysis of the National Inpatient Sample
Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is considered the most advanced temporary life support which provides complete hemodynamic support in addition to gas exchange. There is limited data available on the impact of hyperlipidemia (HLD) on VA-ECMO patients. We sought to examine the national inpatient sample (NIS) database to describe in-hospital outcomes among these patients.
Methods: The NIS was searched for hospitalizations of adult VA-ECMO patients with and without a concomitant diagnosis of HLD for the years 2019 and 2020. The primary outcome was inpatient mortality.
Results: This study included 3,885 VA-ECMO patients, of which 1,082 (27.8%) patients had HLD. VA-ECMO patients with HLD had higher prevalence of hypertension (57.3% vs. 71.4%, p <0.001), and chronic kidney disease (26.3% vs. 17.0 %, p <0.001) compared to VA-ECMO patients without HLD. In-hospital mortality was higher among those with HLD (61.5 % vs. 45.5%, p <0.001). Multivariate regression showed that VA-ECMO patients with HLD had higher inpatient mortality (OR 1.371, 95% CI 1.332-1.410, p <0.001). On secondary analysis, patients had higher odds of having ventricular arrhythmia (OR 1.472, 95% CI 1.416-1.531, p <0.001), acute kidney failure (OR 1.394, 95% CI 1.359-1.429, p <0.001), intracranial hemorrhage (OR 1.157, 95% CI 1.099-1.219, p <0.001), DVT (OR 1.252, 95% CI 1.200-1.306, p < 0.001), and sepsis (OR 1.226, 95% CI 1.195-1.257, p <0.001) compared to VA-ECMO patients without HLD.
Conclusion: In this nationally representative population‐based retrospective cohort study, HLD was associated with higher mortality and worse outcomes among VA-ECMO patients.