Date of Presentation
5-2-2024 12:00 AM
College
Rowan-Virtua School of Osteopathic Medicine
Poster Abstract
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States and has been found to play a significant role in cardiovascular disease risk through several mechanisms including dyslipidemia, insulin resistance, coagulability, and inflammation. Acute-on-chronic liver disease continues to contribute to worse health outcomes via acute hepatitis.
Methods: This case-control study investigated the relationship between NAFLD and acute hepatitis using data extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients with acute hepatitis with and without NAFLD. Using multivariate logistics to adjust for confounders, the primary outcome was inpatient mortality, and the secondary outcomes were hospital length of stay (LOS), and total hospital charges.
Results: This study included 208,145 patients with acute hepatitis, of which 12,406 patients had NAFLD. The study found a statistically significant higher inpatient mortality (OR:1.041, 95% CI:1.1.036-1.046, p <0.001) among those with acute hepatitis and NAFLD. While mean LOS and hospital charges were less for patients with acute hepatitis and NAFLD (6.1days vs. 6.0days, p <0.001; $68,745 vs. $67,460, p <0.001). Secondary analysis found that patients with acute hepatitis and NAFLD had statistically significantly higher odds of high output heart failure, shock, arrhythmias and acute kidney injury compared to those with acute hepatitis and no NAFLD.
Conclusion: In this nationally representative population‐based case-control study, acute hepatitis with NAFLD was associated with higher inpatient mortality and worse outcomes compared to those with acute hepatitis alone.
Keywords
NAFLD, acute hepatitis, hospital mortality, inpatient mortality, health outcomes, Non-alcoholic Fatty Liver Disease, Liver Diseases, Hepatitis
Disciplines
Digestive System | Digestive System Diseases | Gastroenterology | Medicine and Health Sciences | Nutritional and Metabolic Diseases | Pathological Conditions, Signs and Symptoms
Document Type
Poster
Included in
Digestive System Commons, Digestive System Diseases Commons, Gastroenterology Commons, Nutritional and Metabolic Diseases Commons, Pathological Conditions, Signs and Symptoms Commons
Clinical Outcomes for Patients with NAFLD and Acute Hepatitis: An Analysis of the National Inpatient Sample
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States and has been found to play a significant role in cardiovascular disease risk through several mechanisms including dyslipidemia, insulin resistance, coagulability, and inflammation. Acute-on-chronic liver disease continues to contribute to worse health outcomes via acute hepatitis.
Methods: This case-control study investigated the relationship between NAFLD and acute hepatitis using data extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients with acute hepatitis with and without NAFLD. Using multivariate logistics to adjust for confounders, the primary outcome was inpatient mortality, and the secondary outcomes were hospital length of stay (LOS), and total hospital charges.
Results: This study included 208,145 patients with acute hepatitis, of which 12,406 patients had NAFLD. The study found a statistically significant higher inpatient mortality (OR:1.041, 95% CI:1.1.036-1.046, p <0.001) among those with acute hepatitis and NAFLD. While mean LOS and hospital charges were less for patients with acute hepatitis and NAFLD (6.1days vs. 6.0days, p <0.001; $68,745 vs. $67,460, p <0.001). Secondary analysis found that patients with acute hepatitis and NAFLD had statistically significantly higher odds of high output heart failure, shock, arrhythmias and acute kidney injury compared to those with acute hepatitis and no NAFLD.
Conclusion: In this nationally representative population‐based case-control study, acute hepatitis with NAFLD was associated with higher inpatient mortality and worse outcomes compared to those with acute hepatitis alone.