Document Type
Article
Version Deposited
Published Version
Publication Date
7-3-2023
Publication Title
Frontiers in Neuroscience - Autonomic Neuroscience
DOI
10.3389/fnins.2023.1212208
Abstract
High blood pressure, also known as hypertension, is a major risk factor for cardiovascular disease. Salt intake has been shown to have a significant impact on BP, but the mechanisms by which it influences the blood pressure dipping pattern, and 24-h blood pressure remains controversial. This literature review aims to both summarize the current evidence on high salt diet induced hypertension and discuss the epidemiological aspects including socioeconomic issues in the United States and abroad. Our review indicates that a high salt diet is associated with a blunted nocturnal blood pressure dipping pattern, which is characterized by a reduced decrease in blood pressure during the nighttime hours. The mechanisms by which high salt intake affects blood pressure dipping patterns are not fully understood, but it is suggested that it may be related to changes in the sympathetic nervous system. Further, we looked at the association between major blood pressure and circadian rhythm regulatory centers in the brain, including the paraventricular nucleus (PVN), suprachiasmatic nucleus (SCN) and nucleus tractus solitarius (nTS). We also discuss the underlying social and economic issues in the United States and around the world. In conclusion, the evidence suggests that a high salt diet is associated with a blunted, non-dipping, or reverse dipping blood pressure pattern, which has been shown to increase the risk of cardiovascular disease. Further research is needed to better understand the underlying mechanisms by which high salt intake influences changes within the central nervous system.
Recommended Citation
Viggiano J, Coutinho D, Clark-Cutaia MN and Martinez D (2023) Effects of a high salt diet on blood pressure dipping and the implications on hypertension. Front. Neurosci. 17:1212208. doi: 10.3389/fnins.2023.1212208
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
Copyright © 2023 Viggiano, Coutinho, Clark-Cutaia and Martinez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Publication of this article was supported by the Rowan University Libraries 2022-23 Open Access Publishing Fund.