Document Type
Article
Version Deposited
Published Version
Publication Date
12-20-2024
Publication Title
iScience
DOI
10.1016/j.isci.2024.111290
Abstract
Benign prostatic hyperplasia (BPH) is a common condition in aging males, but its underlying pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) play important roles in various diseases, while less studied in prostate. Current study attempts to clarify the expression and functional activities of S1P/S1PRs in the prostate. We discovered that S1P/S1PRs were richly expressed in the prostate, with S1PR1/2/3 localized in the epithelial/stromal compartments, while S1PR4/5 were less expressed. In vitro, S1P/S1PR1/S1PR3 promoted cell proliferation via AKT and ERK1/2 pathways, S1P/S1PR2/S1PR3 enhanced contraction of WPMY-1 cells and human prostate via RhoA/ROCK pathway, while S1P/S1PR1/S1PR2/S1PR3 alleviated the inflammation response via STAT3 pathway. In vivo, S1P and S1PR1/3 agonists (SEW2871, CYM5541) led to prostate enlargement in rats, while S1PR1/3 antagonists (W-146, TY-52156) suppressed testosterone-induced BPH. Overall, this study suggests that S1P/S1PRs play a critical role in the development of BPH and may be a promising therapeutic target for BPH treatment.
Recommended Citation
Liu, Daoquan; Liu, Jianmin; Li, Yan; Du, Lu; Cao, Qingqiong; Yang, Liang; Zhou, Yongying; Chen, Ping; Guo, Yuming; Zeng, Guang; DiSanto, Michael E.; Hu, Weidong; and Zhang, Xinhua, "Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate." (2024). Cooper Medical School of Rowan University Departmental Research. 57.
https://rdw.rowan.edu/cmsru_facpub/57
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
© 2024 The Authors. Published by Elsevier Inc.
iScience is an Open Access journal from Cell Press.