Document Type

Article

Version Deposited

Published Version

Publication Date

2019

Publication Title

Journal of Electrochemical Science and Engineering

DOI

10.5599/jese.652

Abstract

Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.

Comments

Journal of Electrochemical Science and Engineering is an Open Access journal.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Published Citation

Ombwayo, F., Mazzhichette, Z., & Mugweru, A. (2019). Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products. J. Electochem. Sci. Eng. 9(3), 165-174.

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