Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles

Authors

T. R. Flockton
L. Schnorbus
A. Araujo
J. Adams
m. Hammel
Lark Perez, Rowan UniversityFollow

Document Type

Article

Version Deposited

Published Version

Publication Date

2019

Publication Title

Pathogens

DOI

10.3390/pathogens8020055

Abstract

The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.

Comments

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Recommended Citation

Flockton, T.R.; Schnorbus, L.; Araujo, A.; Adams, J.; Hammel, M.; & Perez, L.J. (2019). Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles. Pathogens 2019, 8, 55.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.