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Frontiers in Physiology




The athletic horse, despite being over 50% muscle mass, remains understudied with regard to the effects of exercise and training on skeletal muscle metabolism. To begin to address this knowledge gap, we employed an untargeted metabolomics approach to characterize the exercise-induced and fitness-related changes in the skeletal muscle of eight unconditioned Standardbred horses (four male, four female) before and after a 12-week training period. Before training, unconditioned horses showed a high degree of individual variation in the skeletal muscle metabolome, resulting in very few differences basally and at 3 and 24 h after acute fatiguing exercise. Training did not alter body composition but did improve maximal aerobic and running capacities (


Copyright © 2020 Klein, McKeever, Mirek and Anthony. This open access article was supported by the Rowan University Libraries Open Access Fund.

Published Citation

Klein DJ, McKeever KH, Mirek ET, & Anthony TG. (2020). Metabolomic Response of Equine Skeletal Muscle to Acute Fatiguing Exercise and Training. Frontiers in Physiology, 2020 Feb 18; 11:110. doi: 10.3389/fphys.2020.00110. PMID: 32132934; PMCID: PMC7040365.