Document Type

Article

Version Deposited

Published Version

Publication Date

9-11-2020

Publication Title

International Journal of Nanomedicine

DOI

10.2147/IJN.S259724

Abstract

Purpose: Nucleic acid-based therapies are a promising therapeutic tool. The major obstacle in their clinical translation is their efficient delivery to the desired tissue. We developed a novel nanosized delivery system composed of conjugates of α-tocopherol, polyethyleneimine, and polyethylene glycol (TPP) to deliver nucleic acids.

Methods: We synthesized a panel of TPP molecules using different molecular weights of PEG and PEI and analyzed with various analytical approaches. The optimized version of TPP (TPP

Results: Through a panel of synthesized molecules, TPP

Conclusion: These results indicate that we successfully synthesized the TPP

Comments

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Published Citation

Hossian AKMN, Jois SD, Jonnalagadda SC, & Mattheolabakis G. (2020) Nucleic Acid Delivery with α-Tocopherol-Polyethyleneimine-Polyethylene Glycol Nanocarrier System. International Journal of Nanomedicine. 2020;15:6689-6703 https://doi.org/10.2147/IJN.S259724

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