International Journal of Nanomedicine
Purpose: Nucleic acid-based therapies are a promising therapeutic tool. The major obstacle in their clinical translation is their efficient delivery to the desired tissue. We developed a novel nanosized delivery system composed of conjugates of α-tocopherol, polyethyleneimine, and polyethylene glycol (TPP) to deliver nucleic acids.
Methods: We synthesized a panel of TPP molecules using different molecular weights of PEG and PEI and analyzed with various analytical approaches. The optimized version of TPP (TPP
Results: Through a panel of synthesized molecules, TPP
Conclusion: These results indicate that we successfully synthesized the TPP
Hossian, A K M Nawshad; Jois, Seetharama D; Jonnalagadda, Subash C.; and Mattheolabakis, George, "Nucleic Acid Delivery with α-Tocopherol-Polyethyleneimine-Polyethylene Glycol Nanocarrier System." (2020). Faculty Scholarship for the College of Science & Mathematics. 191.
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Hossian AKMN, Jois SD, Jonnalagadda SC, & Mattheolabakis G. (2020) Nucleic Acid Delivery with α-Tocopherol-Polyethyleneimine-Polyethylene Glycol Nanocarrier System. International Journal of Nanomedicine. 2020;15:6689-6703 https://doi.org/10.2147/IJN.S259724