Document Type
Article
Version Deposited
Published Version
Publication Date
5-27-2021
Publication Title
International Journal of Molecular Sciences
DOI
10.3390/ijms22115707
Abstract
Multiple myeloma (MM), a clonal plasma cell disorder, disrupts the bones' hematopoiesis and microenvironment homeostasis and ability to mediate an immune response against malignant clones. Despite prominent survival improvement with newer treatment modalities since the 2000s, MM is still considered a non-curable disease. Patients experience disease recurrence episodes with clonal evolution, and with each relapse disease comes back with a more aggressive phenotype. Bruton's Tyrosine Kinase (BTK) has been a major target for B cell clonal disorders and its role in clonal plasma cell disorders is under active investigation. BTK is a cytosolic kinase which plays a major role in the immune system and its related malignancies. The BTK pathway has been shown to provide survival for malignant clone and multiple myeloma stem cells (MMSCs). BTK also regulates the malignant clones' interaction with the bone marrow microenvironment. Hence, BTK inhibition is a promising therapeutic strategy for MM patients. In this review, the role of BTK and its signal transduction pathways are outlined in the context of MM.
Recommended Citation
Von Suskil, Max, Kazi N. Sultana, Weam O. Elbezanti, Omar S. Al-Odat, Robert Chitren, Amit K. Tiwari, Kishore B. Challagundla, Sandeep K. Srivastava, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, and Manoj K. Pandey 2021. "Bruton’s Tyrosine Kinase Targeting in Multiple Myeloma" International Journal of Molecular Sciences 22, no. 11: 5707. https://doi.org/10.3390/ijms22115707
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.