Document Type
Article
Version Deposited
Published Version
Publication Date
1-26-2021
Publication Title
Polymers (Basel)
DOI
10.3390/polym13030377
Abstract
Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and π-π stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.
Recommended Citation
Kim KN, Oh KS, Shim J, Schlaepfer IR, Karam SD, & Lee JJ. (2021) Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability. Polymers 13(3):377. doi: 10.3390/polym13030377.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).