Document Type
Article
Version Deposited
Published Version
Publication Date
1-1-2021
Publication Title
Frontiers in Physiology
DOI
10.3389/fphys.2021.715431
Abstract
Tissue engineering of the blood-brain barrier (BBB) in vitro has been rapidly expanding to address the challenges of mimicking the native structure and function of the BBB. Most of these models utilize 2D conventional microfluidic techniques. However, 3D microvascular models offer the potential to more closely recapitulate the cytoarchitecture and multicellular arrangement of in vivo microvasculature, and also can recreate branching and network topologies of the vascular bed. In this perspective, we discuss current 3D brain microvessel modeling techniques including templating, printing, and self-assembling capillary networks. Furthermore, we address the use of biological matrices and fluid dynamics. Finally, key challenges are identified along with future directions that will improve development of next generation of brain microvasculature models.
Recommended Citation
Galpayage Dona KNU, Hale JF, Salako T, Anandanatarajan A, Tran KA, DeOre BJ, Galie PA, Ramirez SH and Andrews AM (2021) The Use of Tissue Engineering to Fabricate Perfusable 3D Brain Microvessels in vitro. Front. Physiol. 12:715431. doi: 10.3389/fphys.2021.715431
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
Copyright © 2021 Galpayage Dona, Hale, Salako, Anandanatarajan, Tran, DeOre, Galie, Ramirez and Andrews. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).