Document Type
Article
Version Deposited
Published Version
Publication Date
11-24-2023
Publication Title
Nature Communications
DOI
10.1038/s41467-023-43428-3
Abstract
Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.
Recommended Citation
Choi W, Mangal U, Park JY, Kim JY, Jun T, Jung JW, Choi M, Jung S, Lee M, Na JY, Ryu DY, Kim JM, Kwon JS, Koh WG, Lee S, Hwang PTJ, Lee KJ, Jung UW, Cha JK, Choi SH, Hong J. Occlusive membranes for guided regeneration of inflamed tissue defects. Nat Commun. 2023 Nov 24;14(1):7687. doi: 10.1038/s41467-023-43428-3. PMID: 38001080; PMCID: PMC10673922.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.