Document Type
Article
Version Deposited
Published Version
Publication Date
1-1-2011
Publication Title
Journal of Nanomaterials
DOI
10.1155/2011/408675
Abstract
Polymeric nanomaterials have the potential to improve upon present chemotherapy delivery methods. They successfully reduce side effects while increasing dosage, increase residence time in the body, offer a sustained and tunable release, and have the ability to deliver multiple drugs in one carrier. However, traditional nanomaterial formulations have not produced highly therapeutic formulations to date due to their passive delivery methods and lack of rapid drug release at their intended site. In this paper, we have focused on a few “smart” technologies that further enhance the benefits of typical nanomaterials. Temperature and pHresponsive drug delivery devices were reviewed as methods for triggering release of encapsulating drugs, while aptamer and ligand conjugation were discussed as methods for targeted and intracellular delivery, with emphases on in vitro and in vivo works for each method.
Recommended Citation
Brewer, E., Coleman, J. & Lowman, A. (2011). Emerging Technologies of Polymeric Nanoparticles in Cancer Drug Delivery, Journal of Nanomaterials, 2011: 1-10.
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This work is licensed under a Creative Commons Attribution 3.0 License.
Comments
This is an Open Access article distributed under a Creative Commons Attribution license.