Date Approved
2-8-2019
Embargo Period
2-11-2019
Document Type
Thesis
Degree Name
M.S., Pharmaceutical Sciences
Department
Chemistry and Biochemistry
College
College of Science & Mathematics
Advisor
Moura-Letts, Gustavo
Committee Member 1
Wu, Chun
Committee Member 2
Jonnalagadda, Subash
Keywords
Cyanopyrrolidines, beta-amino alcohols, matrine alkaloids, synthesis
Subject(s)
Drug development
Disciplines
Medicinal and Pharmaceutical Chemistry
Abstract
Cyanopyrrolidines and beta-Amino alcohols are molecular scaffolds that are highly found in commercially available drugs. We developed a multi-step synthetic method to form a novel library of compounds as inhibitors that share both scaffolds toward potent and selective diabetes therapeutics. Despite the ease for the synthesis of Cyanopyrrolidines, the difficulty of forming high selective beta-Amino alcohols is challenging. We successfully find the best condition for the preference of highly selective mono-alkylation and double-alkylation products and produce them with high yield.
Matrine is an alkaloid found in plants from the genus Sophora and can produce some pharmacological effects such as anti-cancer and anti-tumor effects. We modified the structure of matrine compound by adding aminonitrilles and beta-Amino alcohols scaffolds to its 1st and 2nd generation analogues to produce potential drug therapy.
Recommended Citation
Chen, Xiaotian, "Synthesis of novel library of cyanopyrrolidinyl beta-amino alcohols and matrine alkaloids" (2019). Theses and Dissertations. 2632.
https://rdw.rowan.edu/etd/2632
