Date Approved

8-16-2019

Embargo Period

8-19-2019

Document Type

Thesis

Degree Name

M.S. Pharmaceutical Sciences

Department

Chemistry & Biochemistry

College

College of Science & Mathematics

First Advisor

Jonnalagadda, Subash

Second Advisor

Mugweru, Amos

Third Advisor

Ramanujachary, Kandalam

Subject(s)

Heterocyclic compounds; Drug development

Disciplines

Medicinal and Pharmaceutical Chemistry

Abstract

Heterocyclic compounds play an important role in pharmaceutical drug development. Several natural products and biologically active compounds contain heterocyclic motifs in them. Multicomponent coupling reactions offer an excellent platform for the synthesis of diverse libraries of heterocyclic compounds. We have been working on the synthesis of novel heterocyclic small molecules utilizing reactions such as Baylis-Hillman reaction, Passerini reaction, Click reaction, reductive amination aldol condensation, etc.

In the current project, we prepared three series of heterocyclic compounds using Passerini and Baylis-Hillman reactions as key steps. Owing to the importance of heterocyclic chemistry in drug discovery and the ease of synthesis, the current work would be of interest to medicinal and natural product chemists.

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