M.S. Pharmaceutical Sciences
Chemistry & Biochemistry
College of Science & Mathematics
Committee Member 1
Committee Member 2
metronidazole, Baylis-Hillman reaction
Imidazoles; Drug development
Medicinal and Pharmaceutical Chemistry
Imidazoles are heterocyclic small molecules that play a major role in medicinal chemistry and drug discovery. There are several drugs in the market which contain imidazoles as the pharmacophore. Metronidazole, an imidazole containing compound, is a prominent antibiotic and antiprotozoal medication used for the treatment of a variety of infections such as amoebiasis, trichomoniasis, bacterial vaginosis, etc. The current work involves the synthesis of small molecule libraries of imidazoles derived from metronidazole using Baylis-Hillman (BH) reaction. BH reaction is a carbon-carbon bond forming reaction and involves the coupling of aldehydes or imines with activated alkenes such as acrylates, acrolein, or vinyl ketones to produce functionalized allylic alcohols and amines. These products were further functionalized with metronidazole derived amines for potential use as therapeutic agents.
Morgan, Drew Christopher, "Development of functionalized imidazoles as potential therapeutical agents" (2019). Theses and Dissertations. 2730.