PhD Doctor of Philosophy
Henry M. Rowan College of Engineering
Byrne, Mark E.
ocular drug delivery, silicone hydrogels, biomaterials
Drug delivery devices; Contact lenses
Biomedical Engineering and Bioengineering
There is a need for next generation silicone hydrogel biomaterials with greater compositional flexibility and tailorable material properties for advanced manufacturing and new applications for ocular drug delivery. Poly(DMS-R11-co-TRIS-co-DMA-co-PEG200DMA-co-DEAEM-co-DADMAC) silicone hydrogel contact lenses were synthesized with macromolecular memory and showed 7-day in vitro release of latanoprost acid via a microfluidic platform with controlled release and improved drug payload capacity compared to control lenses. Six newly synthesized silicone macromers were then incorporated into contact lens formulations for the first time to produce a novel, improved platform. Various silicone macromer structures showed significantly improved solubility with TRIS and DMA with components ranging from 0-60% by volume. A thorough analysis of these materials was done to show how the formulation composition, silicone macromer chemistry and structure, and crosslinker length and concentration affected key lens properties: optical clarity, water uptake, elastic modulus, oxygen permeability, and contact angle. This work demonstrates the potential of next-generation silicone hydrogel materials with tailorable properties and broadened potential for use as drug delivery platforms for ocular therapeutics and biomedical applications.
Wuchte, Liana D., "Synthesis and characterization of novel silicon hydrogel biomaterials with advanced properties for ocular drug delivery" (2020). Theses and Dissertations. 2826.
Available for download on Tuesday, July 01, 2025