Date Approved

6-30-2020

Embargo Period

7-1-2025

Document Type

Dissertation

Degree Name

PhD Doctor of Philosophy

Department

Biomedical Engineering

College

Henry M. Rowan College of Engineering

First Advisor

Byrne, Mark E.

Second Advisor

Beachley, Vincent

Third Advisor

Staehle, Mary

Keywords

ocular drug delivery, silicone hydrogels, biomaterials

Subject(s)

Drug delivery devices; Contact lenses

Disciplines

Biomedical Engineering and Bioengineering

Abstract

There is a need for next generation silicone hydrogel biomaterials with greater compositional flexibility and tailorable material properties for advanced manufacturing and new applications for ocular drug delivery. Poly(DMS-R11-co-TRIS-co-DMA-co-PEG200DMA-co-DEAEM-co-DADMAC) silicone hydrogel contact lenses were synthesized with macromolecular memory and showed 7-day in vitro release of latanoprost acid via a microfluidic platform with controlled release and improved drug payload capacity compared to control lenses. Six newly synthesized silicone macromers were then incorporated into contact lens formulations for the first time to produce a novel, improved platform. Various silicone macromer structures showed significantly improved solubility with TRIS and DMA with components ranging from 0-60% by volume. A thorough analysis of these materials was done to show how the formulation composition, silicone macromer chemistry and structure, and crosslinker length and concentration affected key lens properties: optical clarity, water uptake, elastic modulus, oxygen permeability, and contact angle. This work demonstrates the potential of next-generation silicone hydrogel materials with tailorable properties and broadened potential for use as drug delivery platforms for ocular therapeutics and biomedical applications.

Available for download on Tuesday, July 01, 2025

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