M.S. Mechanical Engineering
Henry M. Rowan College of Engineering
Miri, Amir K.
hydrogels, bioprinting, extrusion manufacturing, discrete element modeling, forces
Materials Science and Engineering | Mechanical Engineering
Hydrogels are widely used in extrusion bioprinting as bioinks. Understanding how the hydrogel microstructure affects the bioprinting process aids researchers in predicting the behavior of biological components. Current experimental tools are unable to measure internal forces and microstructure variations during the bioprinting process. In this work, discrete element modeling was used to study the internal interactions and the elastic deformation of the molecular chains within hydrogel networks during the extrusion process. Two-dimensional models of hydrogel extrusions were created in Particle Flow Code (PFC; Itasca Co., Minneapolis, MN). For our model's calibration, hydrogel compression testing was used in which a cluster of particles is pushed in the vertical direction with a confined load similar to the uniaxial compression test. The parameter sensitivity study was performed using a set of parameters, e.g., coefficient of friction, restitution coefficient, and stiffness. Force distribution among the particles during the extrusion process was then predicted using the results of the study. Using this model, we analyzed the distribution of internal forces.
Boddu, Rohit, "Discrete element modeling of hydrogel extrusion" (2021). Theses and Dissertations. 2865.