DEVELOPMENT OF NEW CHEMICAL PROBES TO DELINEATE THE POLYAMINE REGULATION & MOLECULAR STRATEGIES TO UNRAVEL PROTEIN POLYAMINATION
M.S. Pharmaceutical Sciences
Chemistry and Biochemistry
College of Science & Mathematics
Venkatesh V. Nemmara, Ph.D.
Committee Member 1
K. Ramanujam Chary, Ph.D.
Committee Member 2
Subash Jonnalagadda, Ph.D.
Medicinal-Pharmaceutical Chemistry | Physical Sciences and Mathematics
Polyamines such as putrescine, spermidine, and spermine modulate critical cellular processes, including gene expression and cell proliferation. Cellular polyamine regulation is a complex mechanism controlled by three different proteins: Ornithine decarboxylase (ODC), Antizyme (OAZ), and Antizyme Inhibitor (AZIN). While ODC is directly involved in polyamine biosynthesis, OAZ, and AZIN regulate the ODC activity via protein-protein interactions. The dysregulation of ODC, OAZ, and AZIN leads to elevated polyamines in numerous pathologies, making them attractive targets for controlling polyamine levels. Besides regulating polyamine synthesis, OAZ modulates polyamine transport. However, the precise mechanism remains elusive. In this research, we discuss our approach to bridging the current knowledge gap on polyamine regulators. Furthermore, we will highlight our chemical strategies to elucidate the functional impacts of protein polyamination.
Tulluri, Vennela, "DEVELOPMENT OF NEW CHEMICAL PROBES TO DELINEATE THE POLYAMINE REGULATION & MOLECULAR STRATEGIES TO UNRAVEL PROTEIN POLYAMINATION" (2023). Theses and Dissertations. 3106.