Date Approved

11-23-2023

Embargo Period

11-27-2023

Document Type

Thesis

Degree Name

Master of Science (M.S.) Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Ping Lu, Ph.D.

Committee Member 1

Xiao Hu, Ph.D.

Committee Member 2

Zhihong Wang, Ph.D.

Keywords

doxorubicin; electrospinning; ethyl cellulose; nanofibers; phase change material; stimuli-responsive delivery

Subject(s)

Polymeric drug delivery systems; Electrospinning

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry | Physical Sciences and Mathematics

Abstract

In this study, ethyl cellulose (EC) nanofibers loaded with either Rhodamine B (RhB) or Doxorubicin HCl (DOX) and phase change materials (PCM) were fabricated by blend electrospinning. EC is a cellulose derivative widely used as an excipient in the pharmaceutical industry and an ideal polymer for controlled drug release. Lauric acid (LA) and stearic acid (SA) were used as a material with a melting point close to physiological body temperature. Good drug-polymer compatibility and an amorphous distribution of drugs were shown by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The release rate of RhB was shown to be dependent on both drug and PCM loading at 37°C. Samples containing phase change material also showed an increased release rate of 8% RhB when the temperature was increased from 37 °C to 40 °C. A stimuli-controlled release of DOX was demonstrated by an increase of 27% and 41% release rate at pH 7.4 and pH 4, respectively, when the temperature was increased from 37 °C to 40 °C. The comparison of RhB and DOX showed the influence of the selected drug on release rate. The reported electrospun drug delivery system shows promise for the temperature-responsive release of DOX over an extended time-period. This approach may prove useful in the treatment of solid tumors while reducing side effects and improving patient compliance and outcomes.

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