Molecular Biology of the Cell
ASCB/EMBO 2017 Annual Meeting
Cyclin C is a component of the mediator complex of RNA polymerase II that localizes to the nucleus under normal conditions. In response to stress, cyclin C translocates to the cytosol and mitochondria and mediates stress‐induced mitochondrial fission and apoptosis. The molecular mechanisms by which cyclin C induces mitochondrial fission are unknown. Using in vitro experimental approaches, we sought to investigate the mechanistic basis of cyclin C mediated mitochondrial fission.
Ganesan, Vidyaramanan; Cooper, Katrina F; and Strich, Randy, "Mechanistic Insights into the Regulation of Mitochondrial Fission by Cyclin C" (2017). School of Osteopathic Medicine Faculty Scholarship. 118.
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Ganesan V, Cooper KF, Strich R. Mechanistic insights into the regulation of mitochondrial fission by cyclin C [Conference Abstract P3272, p. Tuesday 350-351]. Molecular Biology of the Cell. 2017 Dec 15;28(26):3727. doi: 10.1091/mbc.E17-10-0618. PMID: 29237772. PMCID: PMC5739290.