Document Type
Article
Version Deposited
Published Version
Publication Date
1-1-2018
Publication Title
Child Neurology Open
DOI
10.1177/2329048X18786799
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a neurologic disorder characterized by hyperactivity/impulsivity and/or inattentiveness, with genetic and environmental factors contributing to the disorder. With the growing recognition of the microbiome's role in many neurological disorders, the authors propose that it may also be implicated in ADHD. Here, we describe several evolving areas of research to support this hypothesis. First, a unique composition of gut bacteria has been identified and linked to behaviors in ADHD. Second, our research found an increased incidence of 2 gastrointestinal symptoms (constipation and flatulence) in children with ADHD, as compared to controls. Finally, emerging data may be interpreted to suggest that immune dysregulation in ADHD be associated with an altered microbiome, low-grade inflammation, and gastrointestinal dysfunction. Although more studies are needed to elucidate exact mechanisms and causality, we propose that an altered microbiome, gastrointestinal symptoms, and immune dysregulation may be associated with the ADHD phenotypes.
Recommended Citation
Ming X, Chen N, Ray C, Brewer G, Kornitzer J, Steer RA. A gut feeling: A hypothesis of the role of the microbiome in attention-deficit/hyperactivity disorders. Child Neurology Open. 2018 Jul 11;5:2329048X18786799. eCollection 2018. doi: 10.1177/2329048X18786799. PMID: 30023407. PMCID: PMC6047248.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Included in
Digestive, Oral, and Skin Physiology Commons, Digestive System Commons, Gastroenterology Commons, Medical Neurobiology Commons, Nervous System Commons, Nervous System Diseases Commons, Neurology Commons, Neuroscience and Neurobiology Commons, Neurosciences Commons, Pathological Conditions, Signs and Symptoms Commons
