Document Type
Article
Version Deposited
Published Version
Publication Date
11-1-2024
Publication Title
Journal of Extracellular Biology
DOI
10.1002/jex2.70017
Abstract
The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack of efficacy, failure to achieve clinical endpoints, and dose-limiting toxicities. Successful efforts have been characterized by the development of therapeutics designed to specifically deliver optimal and effective dosing to tumour cells while minimizing off-target toxicity. Much effort has been devoted to the rational design and application of synthetic nanoparticles to serve as targeted therapeutic delivery vehicles. Several challenges to the successful application of this modality as delivery vehicles include the induction of a protracted immune response that results in their rapid systemic clearance, manufacturing cost, lack of stability, and their biocompatibility. Extracellular vesicles (EVs) are a heterogeneous class of endogenous biologically produced lipid bilayer nanoparticles that mediate intercellular communication by carrying bioactive macromolecules capable of modifying cellular phenotypes to local and distant cells. By genetic, chemical, or metabolic methods, extracellular vesicles (EVs) can be engineered to display targeting moieties on their surface while transporting specific cargo to modulate pathological processes following uptake by target cell populations. This review will survey the types of EVs, their composition and cargoes, strategies employed to increase their targeting, uptake, and cargo release, and their potential as targeted anti-cancer therapeutic delivery vehicles.
Recommended Citation
Jackson Cullison, Stephanie R; Flemming, Joseph P; Karagoz, Kubra; Wermuth, Peter J; and Mahoney, Mỹ G, "Mechanisms of Extracellular Vesicle Uptake and Implications for the Design of Cancer Therapeutics" (2024). Rowan-Virtua School of Osteopathic Medicine Departmental Research. 232.
https://rdw.rowan.edu/som_facpub/232
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Published Citation
Jackson Cullison SR, Flemming JP, Karagoz K, Wermuth PJ, Mahoney MG. Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics. J Extracell Biol. 2024 Oct 30;3(11):e70017. doi: 10.1002/jex2.70017. PMID: 39483807; PMCID: PMC11522837.
Included in
Cancer Biology Commons, Cell Biology Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons, Medical Pharmacology Commons, Nanomedicine Commons, Neoplasms Commons